Total synthesis of drimane sesquiterpenes from S-(+)-carvone (part 5)

…, AA Verstegen-Haaksma, BJM Jansen, A de Groot

Index: Groot, Aede de; Jansen, Ben J. M. Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2034 - 2035

Full Text: HTML

Citation Number: 14

Abstract

Conjugate addition of potassium cyanide to S-(+)-carvone followed by annulation with methyl vinyl ketone nitrile 4 in high yield. Methylation of 4, removal of the isopropenyl group and the introduction of C-12 via formylation then gave the unsaturated keto lactone 21 which