Tetrahedron Letters

A convenient synthesis of benzannelated diazacycloalkanes by reductive cleavage of 1, 2-polymethylenebenzimidazoles

T Shvidenko, K Nazarenko, K Shvidenko, A Kostyuk

Index: Shvidenko, Tatyana; Nazarenko, Kostiantyn; Shvidenko, Konstantin; Kostyuk, Aleksandr Tetrahedron Letters, 2014 , vol. 55, # 1 p. 279 - 281

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Abstract

Abstract A facile procedure for the synthesis of benzannelated diazacycloalkanes 3 is elaborated on the basis of reductive cleavage of 1, 2-polymethylenebenzimidazoles 2 with DIBAL-H. The reduction of the corresponding salts prepared by treatment of 1, 2- polymethylenebenzimidazoles 2 with methyl iodide proceeded differently affording exclusively o-phenylenediamines 10. The limitations and scope of the method were ...