Journal of natural products

(+)-Myristinins A and D from Knema e legans, which Inhibit DNA Polymerase β and Cleave DNA

JZ Deng, SR Starck, S Li, SM Hecht

Index: Maloney, David J.; Deng, Jing-Zhen; Starck, Shelley R.; Gao, Zhijie; Hecht, Sidney M. Journal of the American Chemical Society, 2005 , vol. 127, # 12 p. 4140 - 4141

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Citation Number: 23

Abstract

A survey of crude plant extracts for DNA polymerase β inhibitors resulted in the identification of a methyl ethyl ketone extract prepared from Knema elegans that strongly inhibited the enzyme. Subsequent bioassay-guided fractionation of the extract, using an assay to monitor the activity of DNA polymerase β, led to the isolation of two potent inhibitors,(+)-myristinins A (1) and D (2), which are known flavans having unusual structures.(+)-Myristinins A and D ...