Organic letters

Decarbonylative approach to the synthesis of enamides from amino acids: stereoselective synthesis of the (Z)-aminovinyl-d-cysteine unit of mersacidin

P García-Reynaga, AK Carrillo…

Index: Garcia-Reynaga, Pablo; Carrillo, Angela K.; Vannieuwenhze, Michael S. Organic Letters, 2012 , vol. 14, # 4 p. 1030 - 1033

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Citation Number: 12

Abstract

The prevalence of antibiotic resistance poses a significant public health problem and continues to undermine the achievements that have led to the development of our current antibiotic arsenal. Among these agents, “last line” glycopeptide antibiotics, such as vancomycin, have arguably received the most attention in light of the onset of methicillin-resistant S. aureus (MRSA), a particularly problematic nosocomial infection. However, the emergence of new ...

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