The Journal of Organic Chemistry

Facile synthesis of N-acyl-2-pyrrolines

GA Kraus, K Neuenschwander

Index: Kraus, George A.; Neuenschwander, Kent Journal of Organic Chemistry, 1981 , vol. 46, # 23 p. 4791 - 4792

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Citation Number: 58

Abstract

In conjunction with our studies of the amidoalkylation reaction,'multigram quantities of N-acyl- 2-pyrrolines (1) were needed. Interestingly, only a few methods for the synthesis of this class of compounds had been reported. Stille and co-workers prepared 1 by a novel transition metal mediated isomerization of N-acyl-3-pyrrolines2 and also cyclized (acy1amino) butyraldehydes to produce le3 Although these methods are excellent for qmall-scale ...

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