Discovery of tetrahydrotetramethylnaphthalene analogs as adult T-cell leukemia cell-selective proliferation inhibitors in a small chemical library constructed based on …
M Nakamura, T Hamasaki, M Tokitou, M Baba…
Index: Nakamura, Masahiko; Hamasaki, Takayuki; Tokitou, Maiko; Baba, Masanori; Hashimoto, Yuichi; Aoyama, Hiroshi Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4740 - 4746
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Citation Number: 14
Abstract
Adult T cell leukemia (ATL), caused by infection of human T-lymphotropic virus type 1 (HTLV- 1), has a poor prognosis and curative therapy is unavailable, so it is important to find or design superior lead compounds for the drug treatment of ATL. We used our micro-reversed fragment-based drug design hypothesis and multi-template hypothesis to extract the tetrahydrotetramethylnaphthalene (TMN) skeleton from tamibarotene, a useful ...
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