Identification of the first retinoid X receptor homodimer antagonist

…, GE Croston, KS Flatten, RA Heyman…

Index: Koch; Dardashti; Hebert; White; Croston; Flatten; Heyman; Nadzan Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3229 - 3234

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Citation Number: 58

Abstract

Introduction. Retinoids regulate numerous biological functions, including cell growth, cellular differentiation, and modulation of apoptosis. 1, 2 Retinoids are currently employed for the treatment of dermatological diseases such as acne and psoriasis3 and are being studied in clinical trials for their potential in the treatment of oncological diseases. 4 The retinoid receptors mediate the biological effects of retinoid ligands and are members of the ...

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