Tetrahedron Letters

Synthesis of SB 222618. A potential PDE IV inhibitor

JJ Conde, W Mendelson

Index: Conde, Jose J.; Mendelson, Wilford Tetrahedron Letters, 2000 , vol. 41, # 6 p. 811 - 814

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Citation Number: 19

Abstract

SB 222618 (1) has been a target of synthetic chemists at SmithKline Beecham owing to its potential PDE IV 1 inhibitor activity against inflammatory diseases such as asthma. Apart from its biological activity, this cyclohexanol provided the opportunity to explore the non-obvious construction of the quaternary C 4 of 1 whose retrosynthesis is shown below (Scheme 1). ... As depicted in Scheme 1, SB 222618 (1) could be obtained via the Sonogashira 2 coupling protocol between ...

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