Selective epoxidation of eicosa-cis-5, 8, 11, 14-tetraenoic (arachidonic) acid and eicosa-cis-8, 11, 14-trienoic acid

EJ Corey, H Niwa, JR Falck

Index: Corey,E.J. et al. Journal of the American Chemical Society, 1979 , vol. 101, p. 1586 - 1587

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Citation Number: 177

Abstract

The key role of arachidonic acid (1) as the predecessor of a large family of biologically important substances including prostaglandins (PG's), thromboxanes, SRS-A, HETE, and prostacyclin (members of the" arachidonic cascade" I) depends on highly selective enzymatic oxidation of this substrate as a primary event. Similarly, selective oxidation of eicosacis-8, 11, 14-trienoic acid (2) initiates the series of transformations leading to PG1 ...