Tris (2, 4, 6-tribromophenoxy) dichlorophosphorane: A novel condensing agent for rapid internucleotidic bond formation in the phosphotriester approach

H Hotoda, T Wada, M Sekine, T Hata

Index: Hotoda, Hitoshi; Wada, Takeshi; Sekine, Mitsuo; Hata, Tsujiaki Tetrahedron Letters, 1987 , vol. 28, # 15 p. 1681 - 1684

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Citation Number: 16

Abstract

Abstract A new class of condensing agent, tris (2, 4, 6-tribromophenoxy)- dichlorophosphorane (BDCP), was applied to the oligodeoxyribonucleotide synthesis. This reagent enabled us to perform a rapid internucleotidic bond formation in the phosphotriester approach only in 1 minute via an active phosphorylnitrotriazole intermediate.