Direct and convenient conversion of alcohols to fluorides

J Yin, DS Zarkowsky, DW Thomas, MM Zhao…

Index: Yin, Jingjun; Zarkowsky, Devin S.; Thomas, David W.; Zhao, Matthew M.; Huffman, Mark A. Organic Letters, 2004 , vol. 6, # 9 p. 1465 - 1468

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Citation Number: 69

Abstract

Directly mixing primary, secondary, and tertiary alcohols with n C4F9SO2F-NR3 (HF) 3-NR3 in THF or MeCN results in convenient conversion to the corresponding fluorides in high yields. The readily available reagents are easy to handle, and the mild, almost neutral reaction conditions allow for excellent functional group compatibility. A NR3 (HF) 3/NR3 ratio of≤ 1: 2 gives the highest reactivity.

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