Tetrahedron letters

An efficient and selective tosylation of alcohols with p-toluenesulfonic acid

B Das, VS Reddy, MR Reddy

Index: Das, Biswanath; Reddy, V. Saidi; Reddy, M. Ravinder Tetrahedron Letters, 2004 , vol. 45, # 36 p. 6717 - 6719

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Citation Number: 23

Abstract

Tosylation of alcohols is widely used in organic synthesis. 1 Tosylation is generally carried out 2 with p-toluenesulfonyl chloride or anhydride in the presence of bases. However, these tosylating agents are very reactive and moisture sensitive. p-Toluenesulfonic acid (p-TsOH) has also been used 3 as a tosylating agent but in this case expensive reagents such as trialkyl orthoformates, alkyl ethers or esters are also used. Recently, the synthesis of sulfonates ...

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