Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer
M Shaul, G Abourbeh, O Jacobson, Y Rozen…
Index: Shaul, Mazal; Abourbeh, Galith; Jacobson, Orit; Rozen, Yulia; Laky, Desideriu; Levitzki, Alexander; Mishani, Eyal Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 13 p. 3421 - 3429
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Citation Number: 67
Abstract
The in vivo results with our previously reported irreversible labeled inhibitor [11C]-ML03 suggested that more chemically stable inhibitors, labeled with a longer-lived radioisotope, could be better candidates for molecular imaging of epidermal growth factor receptor (EGFR) positive tumors. On the basis of this hypothesis we synthesized three new irreversible tyrosine kinase (TK) inhibitors with various chemical reactivities. The three ...
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[Mishani, Eyal; Abourbeh, Galith; Jacobson, Orit; Dissoki, Samar; Ben Daniel, Revital; Rozen, Yulia; Shaul, Mazal; Levitzki, Alexander Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5337 - 5348]