Enzymatic halogenation of the phenolic monoterpenes thymol and carvacrol with chloroperoxidase

…, T Krieg, F Hollmann, J Schrader, D Holtmann

Index: Getrey, Laura; Krieg, Thomas; Hollmann, Frank; Schrader, Jens; Holtmann, Dirk Green Chemistry, 2014 , vol. 16, # 3 p. 1104 - 1108

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Citation Number: 23

Abstract

The conversion of the phenolic monoterpenes thymol and carvacrol into antimicrobials by (electro)-chemoenzymatic halogenation was investigated using a chloroperoxidase (CPO) catalyzed process. The CPO catalysed process enables for the first time the biotechnological production of chlorothymol, chlorocarvacrol and bromothymol as well as a dichlorothymol with high conversion rates, total turnover numbers and space time yields of up to 90%, ...