Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase

…, TCP Chang, TR Leverone, DA Ferrick…

Index: Gray; Platz; Chang; Leverone; Ferrick; Kramer Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 111 - 116

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Citation Number: 13

Abstract

A number of compounds were synthesized and tested for their ability to realkylate the phosphonate anion of “aged, soman-inhibited acetylcholinesterase. None were found able to do so, but two of the compounds in particular,[2-(4-pyridyl) ethyl] diethylmethylammonium iodide (6) and its 2-isomer 7, proved able to slow the rate of aging significantly.