Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

…, YL Janin, B Saint-Joanis, P Brodin, S Michel…

Index: Prado, Soizic; Janin, Yves L.; Saint-Joanis, Brigitte; Brodin, Priscille; Michel, Sylvie; Koch, Michel; Cole, Stewart T.; Tillequin, Francois; Bost, Pierre-Etienne Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2177 - 2186

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Citation Number: 45

Abstract

We recently reported that 3, 3-dimethyl-3H-benzofuro [3, 2, f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infection due to their poor bioavailability led to a structure–activity relationship investigation. We wish to report here the preparation of some structural analogues along with their biological effect ...