Tetrahedron

Aromatic δ-peptides: design, synthesis and structural studies of helical, quinoline-derived oligoamide foldamers

H Jiang, JM Léger, C Dolain, P Guionneau, I Huc

Index: Jiang, Hua; Leger, Jean-Michel; Dolain, Christel; Guionneau, Philippe; Huc, Ivan Tetrahedron, 2003 , vol. 59, # 42 p. 8365 - 8374

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Citation Number: 92

Abstract

Oligoamides of 8-amino-4-isobutoxy-2-quinolinecarboxylic acid were designed and synthesized, and their helical structures were characterized in the solid state by single crystal X-ray diffraction, and in solution by 1H NMR. The monomer methyl 4-isobutoxy-8- nitro-2-quinolinecarboxylate is easily prepared in three steps from 2-nitroaninile and dimethyl acetylene dicarboxylate. Successive hydrogenations of nitro groups, ...