Towards a modern definition of vitamin E—evidence for a quinone hypothesis

…, O Jankowski, E Lee, V Kheifets, R Komatsuzaki…

Index: Shrader, William D.; Amagata, Akiko; Barnes, Adam; Hinman, Andrew; Jankowski, Orion; Lee, Edgar; Kheifets, Viktoria; Komatsuzaki, Ryo; Mollard, Paul; Murase, Katsuyuki; Rioux, Patrice; Wesson, Kieron; Miller, Guy Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 391 - 395

Full Text: HTML

Citation Number: 5

Abstract

We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, α-tocopherol quinone (ATQ); an oxidative metabolite of α-tocopherol. ATQ is a potent cellular protectant against oxidative stress, whose biological activity is dependent upon its ability to undergo reversible two-electron redox cycling. ATQ is orally bioavailable, with a favorable pharmacokinetic profile and has demonstrated a beneficial clinical ...

Related Articles:

Improved general method of ortho alkylation of phenols using alkyl isopropyl sulfide, sulfuryl chloride, and triethylamine. An expedient synthesis of representative …

[Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al. Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497]

Improved general method of ortho alkylation of phenols using alkyl isopropyl sulfide, sulfuryl chloride, and triethylamine. An expedient synthesis of representative …

[Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al. Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497]

Improved general method of ortho alkylation of phenols using alkyl isopropyl sulfide, sulfuryl chloride, and triethylamine. An expedient synthesis of representative …

[Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al. Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497]

Improved general method of ortho alkylation of phenols using alkyl isopropyl sulfide, sulfuryl chloride, and triethylamine. An expedient synthesis of representative …

[Inoue, Seiichi; Ikeda, Hiroshi; Sato, Shuichi; Horie, Kiyohiro; Ota, Tomomi; et al. Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5495 - 5497]

More Articles...