Tetrahedron

7-Polyfluoroalkylnorkhellins: synthesis and reactions with alkyl mercaptoacetates

VY Sosnovskikh, BI Usachev, II Vorontsov

Index: Sosnovskikh, Vyacheslav Ya.; Usachev, Boris I.; Vorontsov, Ivan I. Tetrahedron, 2003 , vol. 59, # 14 p. 2549 - 2554

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Citation Number: 19

Abstract

The natural furochromone khellin (4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one), obtained from the fruits and seeds of Ammi visnaga L. possesses a high antiatherosclerotic and lipid-altering activity 6 and is the active constituent of many modern medicines. 7 In view of the unique biological properties displayed by khellin on the one hand and by many fluorinated heterocyclic compounds 8 on the other hand, we have described recently 9 the synthesis of 7-trifluoro- and ...