Chemistry Letters

Facile synthesis of α-fluoro-β-ketoesters from polyfluoroalkenes

…, A Takaoka, H Iwakiri, S Kubota, SRF Kagaruki

Index: Ishikawa, Nobuo; Takaoka, Akio; Iwakiri, Hiroshi; Kubota, Satoshi; Kagaruki, S. R. F. Chemistry Letters, 1980 , p. 1107 - 1110

Full Text: HTML

Citation Number: 15

Abstract

Alkyl 2-chloro-1, 2, 2-trifluoroethyl ketones and aryl 1, 2, 2, 2-tetrafluoroethyl ketones were respectively prepared by the Friedel–Crafts acylation of trifluoroethene and by the Grignard arylation of N, N-diethyl-1, 2, 2, 2-tetrafluoropropionamide, a hydrolyzed product of hexafluoropropene–diethylamine adduct. These alkyl and aryl polyfluoroalkyl ketones were subjected to base-induced dehydrohalogenation, and resulting trifluorovinyl ketones were ...