Journal of fluorine chemistry

A gas-solid-phase microchemical method for the synthesis of acetyl hypofluorite

DM Jewett, JF Potocki, RE Ehrenkaufer

Index: Jewett, D. M.; Potocki, J. F.; Ehrenkaufer, R. E. Journal of Fluorine Chemistry, 1984 , vol. 24, p. 477 - 484

Full Text: HTML

Citation Number: 67

Abstract

Abstract The useful electrophilic fluorinating agent, acetyl hypofluorite, was obtained by passing F 2 diluted in N 2 through columns containing complexes of alkali metal acetates with acetic acid. Acetyl hypofluorite obtained from KOAc (HOAc) 1.5 and 0.14% F 2 in N 2 was reacted with tri-O-acetyl-D-glucal in CCl 3 F to obtain tetra-O-acetyl-2-deoxy-2-fluoro-D- glucose in 68% yield based on F2. These conditions are appropriate to the radiosynthesis ...

Related Articles:

First direct fluorination of tyrosine-containing biologically active peptides

[Hebel, D.; Kirk, K.L.; Cohen, L.A.; Labroo, V.M. Tetrahedron Letters, 1990 , vol. 31, # 5 p. 619 - 622]

Acetyl hypofluorite, the first member of a new family of organic compounds

[Rozen, Shlomo; Lerman, Ori; Kol, Moshe Journal of the Chemical Society, Chemical Communications, 1981 , # 10 p. 443 - 444]

Isolation and characterization of acetyl hypofluorite

[Appelman, Evan H.; Mendelsohn, Marshall H.; Kim, Hyunyong Journal of the American Chemical Society, 1985 , vol. 107, # 23 p. 6515 - 6518]

More Articles...