Tetrahedron Letters

A novel method for the synthesis of aryl trihalomethyl sulfones and their derivatization: the search for new sulfone fungicides

MD Korzyński, KM Borys, J Białek, Z Ochal

Index: Korzynski, Maciej D.; Borys, Krzysztof M.; Bialek, Justyna; Ochal, Zbigniew Tetrahedron Letters, 2014 , vol. 55, # 3 p. 745 - 748

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Citation Number: 6

Abstract

Abstract A novel method for the preparation of bioactive aryl trihalomethyl sulfones is reported. An iodination reaction with iodine bromide is applied for the synthesis of difluoroiodomethyl aryl sulfones. A series of difluoroiodomethylsulfonyl group bearing derivatives is afforded, including nitroanilines and benzimidazoles. Biological studies show high fungicidal activity for a number of the synthesized sulfones.

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