Synthesis and in vitro cytotoxic evaluation of 1, 3-bisubstituted and 1, 3, 9-trisubstituted β-carboline derivatives

…, H Chen, X Hou, H Guan, Q Chen, Y Ma, A Xu

Index: Cao, Rihui; Peng, Wenlie; Chen, Hongsheng; Hou, Xuerui; Guan, Huaji; Chen, Qi; Ma, Yan; Xu, Anlong European Journal of Medicinal Chemistry, 2005 , vol. 40, # 3 p. 249 - 257

Full Text: HTML

Citation Number: 65

Abstract

A series of novel 1, 3-bisubstituted and 1, 3, 9-trisubstituted β-carboline derivatives was synthesized from the starting material l-tryptophan. Cytotoxic activities of these compounds were investigated in vitro. The results showed that 1, 3, 9-trisubstituted β-carboline derivatives had higher cytotoxic activities in vitro than the corresponding 1, 3-bisubstituted compounds. Among all the synthesized 1, 3, 9-trisubstituted β-carboline derivatives, the ...

Related Articles:

Efficient and Practical One??Pot Conversions of N??Tosyltetrahydroisoquinolines into Isoquinolines and of N??Tosyltetrahydro?螃漫?carbolines into β??Carbolines through …

[Dong, Jing; Shi, Xiao-Xin; Yan, Jing-Jing; Xing, Jing; Zhang, Qiang; Xiao, Sen European Journal of Organic Chemistry, 2010 , # 36 p. 6987 - 6992]

Degradation of Tetrahydro-β-carbolines in the Presence of Nitrite: HPLC-MS Analysis of the Reaction Products

[Salvi; Choughuley Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 10 p. 986 - 988]

Synthesis and antitumor activity of β-carboline 3-(substituted-carbohydrazide) derivatives

[Barbosa, Valeria Aquilino; Formagio, Anelise S. Nazari; Savariz, Franciele Cristina; Foglio, Mary Ann; Spindola, Humberto Moreira; De Carvalho, Joao Ernesto; Meyer, Emerson; Sarragiotto, Maria Helena Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6400 - 6408]

Synthesis and Herbicidal Activity Evaluation of Novel β-Carboline Derivatives

[Weng, Qunfang; Huang, Jingfei; Zeng, Yong; Deng, Yueye; Hu, Meiying Molecules, 2012 , vol. 17, # 4 p. 3969 - 3980]

Synthesis and antitumor activity of β-carboline 3-(substituted-carbohydrazide) derivatives

[Barbosa, Valeria Aquilino; Formagio, Anelise S. Nazari; Savariz, Franciele Cristina; Foglio, Mary Ann; Spindola, Humberto Moreira; De Carvalho, Joao Ernesto; Meyer, Emerson; Sarragiotto, Maria Helena Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6400 - 6408]

More Articles...