Palladium??Catalyzed Asymmetric Allylic Alkylation of Ketone Enolates

BM Trost, GM Schroeder

Index: Trost, Barry M.; Schroeder, Gretchen M. Chemistry - A European Journal, 2005 , vol. 11, # 1 p. 174 - 184

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Citation Number: 97

Abstract

Abstract Palladium-catalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one equivalent of trimethytin chloride as a Lewis acid, 1, 2-dimethoxyethane as the solvent, and a catalytic amount of a chiral palladium complex formed from π-allyl ...