Imidazo [1, 5-d][1, 2, 4] triazines as potential antiasthma agents

…, JA Brockman, WA Hallett, JW Hanifin…

Index: Paul, Rolf; Brockman, John A.; Hallett, W. A.; Hanifin, John W.; Tarrant, M. Ernestine; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1704 - 1716

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Citation Number: 21

Abstract

16 compounds, as measured in vitro, in the human basophil test described by Lichtenstein et al. ld Compounds that were active in the basophil screen were further evaluated for in vivo activity in the mouse passive cutaneous anaphylaxis test (PCA) and in the more demanding animal model of systemic passive anaphylaxis in the guinea pig. Chemistry. The approach to the imidazo [l, 5-d]-[1, 2, 4] triazines3 may be broken down into three steps:(1) the ...