Indenone derivatives: a novel template for peroxisome proliferator-activated receptor γ (PPARγ) agonists

…, SH Jung, SK Kang, KR Kim, SD Rhee…

Index: Ahn, Jin Hee; Shin, Mi Sik; Jung, Sun Ho; Kang, Seung Kyu; Kim, Kwang Rok; Rhee, Sang Dal; Jung, Won Hoon; Yang, Sung Don; Kim, Seung Jun; Woo, Joo Rang; Lee, Jeong Hyung; Cheon, Hyae Gyeong; Kim, Sung Soo Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4781 - 4784

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Citation Number: 57

Abstract

Agonists of peroxisome proliferator-activated receptor γ (PPAR γ) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR γ agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.

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