Synthesis and antitumor activity of diamines containingγ-chloro-β-hydroxypropyl groups

TA Andreyanova, SM Minakova, LF Linberg…

Index: Andreyanova, T. A.; Minakova, S. M.; Linberg, L. F.; Alekseeva, L. M.; Turchin, K. F.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 12 p. 880 - 883 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 12 p. 1460 - 1463

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Abstract

In continuation of the search for antitumor drugs [1], with the aim of elucidating structure- activity relationships, compounds have been obtained which carry~-chloro-fl-hydroxypropyl groups on the nitrogen atoms of diamines. These groups are present in the home-produced drug prospidine (N1N4-di-(T-chloro-fi-hydroxypropyl)-N2N3-dispirotripiperazinium dichloride)[2]. A study has been made of the reactions of ethylenediamine (I), ...