Medicinal Chemistry

Design, synthesis & biological evaluation of some novel quinazolinone scaffolds

RP Modh, AC Patel, KH Chikhalia

Index: Modh, Rahul P.; Patel, Amit C.; Chikhalia, Kishor H. Medicinal Chemistry, 2012 , vol. 8, # 2 p. 182 - 192

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Citation Number: 11

Abstract

In an effort to discover new candidates with improved antimicrobial activities, we synthesized and studied invitro antimicrobial activities of various series of 3-((thiophen-2-yl)-ethyl)-2- (styryl)-quinazolin-4 (3H)-one (3a-3g) and N1-(substituted aryl)-N3-[3-((3, 4-dimethoxy phenyl-2-yl)-ethyl)-4 (3H)-quinazolone-2-yl]-acetonyl semicarbazides (7a-7j) with an intent to overcome multiple drug resistance to the pathogenic strains and to retain psychological ...