Bioorganic chemistry

Monoamine oxidase inhibition by C4-substituted phthalonitriles

CI Manley-King, JJ Bergh, JP Petzer

Index: Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. Bioorganic Chemistry, 2012 , vol. 40, # 1 p. 114 - 124

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Citation Number: 11

Abstract

It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms numerous polar interactions with the polar region of the MAO-B substrate cavity while the C5 side chain extends to, and interacts via Van der Waals interactions with the hydrophobic regions of the enzyme entrance cavity. ...