N-substituted 2′-(aminoaryl) benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping

…, O Müller, T Wieber, T Herz, R Krauss, F Totzke…

Index: Tasler, Stefan; Mueller, Oliver; Wieber, Tanja; Herz, Thomas; Krauss, Rolf; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1349 - 1356

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Citation Number: 24

Abstract

Starting with a hit from vHTS attained by a docking procedure of virtual compounds into ATP pockets of different kinases applying the 4SCan® technology, variations of the adenine mimic resulted in the identification of promising scaffolds, giving rise to in vitro IC50 values in the nanomolar range on different kinases down to 63nM.