Synlett

Pd (II)-Catalyzed Asymmetric Fluorination of α-Aryl-α-cyanophosphonates with the Aid of 2, 6-Lutidine

K Moriya, Y Hamashima, M Sodeoka

Index: Moriya, Ken-Ichi; Hamashima, Yoshitaka; Sodeoka, Mikiko Synlett, 2007 , # 7 p. 1139 - 1142

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Citation Number: 26

Abstract

Abstract We describe herein the catalytic asymmetric fluorination of α-cyanophosphonates using chiral Pd (II)-bisphosphine complexes. While metal complexes failed to promote the reaction alone, a reaction system involving Pd (II) and organic base such as 2, 6-lutidine was developed. The Pd (II) complex activates the substrates through coordination of the nitrile group, and 2, 6-lutidine abstracts an acidic proton, thereby affording the desired ...