Pyridinylimidazole inhibitors of Tie2 kinase

…, N Johnson, JL Adams, J Winkler, M Hansbury

Index: Semones, Marcus; Feng, Yanhong; Johnson, Neil; Adams, Jerry L.; Winkler, Jim; Hansbury, Michael Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4756 - 4760

Full Text: HTML

Citation Number: 33

Abstract

This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC- 315 plasmacytoma xenograft model.