Water promoted one pot three-component synthesis of tetrazoles

…, P Shanmugavelan, S Nagarajan, M Dinesh…

Index: Sathishkumar, Murugan; Shanmugavelan, Poovan; Nagarajan, Sangaraiah; Dinesh, Murugan; Ponnuswamy, Alagusundaram New Journal of Chemistry, 2013 , vol. 37, # 2 p. 488 - 493

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Citation Number: 9

Abstract

A one pot, three component synthesis of tetrazoles via thiourea has been accomplished in water. Water enhances the solubility of a higher number of components in the three component protocol thus promoting the reaction. The synthesis involves a chemoselective exocyclic reaction, regioselective electrocyclisation and a preferred conformational orientation of the tetrazole side chain which are rationalised based on the relative ...