Potential antitumor agents. 52. Carbamate analogs of amsacrine with in vivo activity against multidrug-resistant P388 leukemia

GW Rewcastle, BC Baguley, GJ Atwell…

Index: Rewcastle, Gordon W.; Baguley, Bruce C.; Atwell, Graham J.; Denny, William A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1576 - 1581

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Citation Number: 15

Abstract

Study of a series of aniline-substituted 9-anilinoacridines related to the antileukemic drug amsacrine showed that a 1'-carbamate group provided increased activity against the multidrug-resistant P388/ADR leukemia subline in vivo. Since activity against such resistant tumors is of great clinical significance, a series of acridine-substituted carbamate derivatives were evaluated against both wild-type and ADR/resistant P388 leukemia and the Lewis ...