Solvent-Free indoles addition to carbonyl compounds promoted by CeCl3· 7H2O-NaI-SiO2: An efficient method for the synthesis of streptindole

…, G Foglia, A Giuliani, E Marcantoni, L Sambri

Index: Bartoli, Giuseppe; Bosco, Marcella; Foglia, Gioia; Giuliani, Arianna; Marcantoni, Enrico; Sambri, Letizia Synthesis, 2004 , # 6 p. 895 - 900

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Citation Number: 38

Abstract

Abstract Efficient electrophilic substitution reactions of indoles with various carbonyl compounds proceed easily in solvent-free conditions using CeCl 3· 7H 2 O-NaI-SiO 2 system promoter, to afford the corresponding bis (1H-indol-3-yl) alkanes in high yields. The synthetic value of the present procedure is demonstrated by the synthesis of streptindole (9), human intestinal bacteria metabolite.

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