Synthesis and activity studies of analogues of the rat selective toxicant norbormide

D Rennison, S Bova, M Cavalli, F Ricchelli…

Index: Rennison, David; Bova, Sergio; Cavalli, Maurizio; Ricchelli, Fernanda; Zulian, Alessandra; Hopkins, Brian; Brimble, Margaret A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2963 - 2974

Full Text: HTML

Citation Number: 21

Abstract

Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-5-norbornene-2, 3- dicarboximide](NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. A series of NRB- related analogues were prepared to investigate the structural features responsible for, and the in vitro biological markers indicative of, in vivo lethality of the parent molecule in rats. ...

Related Articles:

α-Oxygen-atom Induced Methylenation of Ketones by CH2 (ZnI) 2

[Ukai; Arioka; Yoshino; Fushimi; Oshima; Utimoto; Matsubara Synlett, 2001 , # 4 p. 513 - 514]

Electrophilic Activation of Acetyl-Substituted Heteroaromatic Compounds

[Klumpp; Garza; Sanchez Jr.; Lau; De Leon Journal of Organic Chemistry, 2000 , vol. 65, # 26 p. 8997 - 9000]

Highly asymmetric dihydroxylation of 1-aryl-1′-pyridyl alkenes

[Wang, Xin; Zak, Mark; Maddess, Mathew; O'Shea, Paul; Tillyer, Richard; Grabowski; Reider, Paul J. Tetrahedron Letters, 2000 , vol. 41, # 25 p. 4865 - 4869]

Highly asymmetric dihydroxylation of 1-aryl-1′-pyridyl alkenes

[Wang, Xin; Zak, Mark; Maddess, Mathew; O'Shea, Paul; Tillyer, Richard; Grabowski; Reider, Paul J. Tetrahedron Letters, 2000 , vol. 41, # 25 p. 4865 - 4869]

Synthesis and reduction of 2, 2??diaryl??1??nitroethylenes by using a chiral and a non chiral NADH model in the pyrrolopyridine series

[Levacher, Vincent; Valque, Claude; Coupa, Sophie; Dupas, Georges; Queguiner, Guy; Bourguignon, Jean Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 4 p. 1211 - 1215]

More Articles...