Synthesis of indolyloxypropanolamines bearing the 2-(1H-indol-3yl)-1, 1-dimethylethyl group: structure—activity studies and anti-hypertensive activity

J Wagnon, B Tonnerre, H Demarne, M Serre…

Index: Wagnon; Plouzane; Tonnerre b.; Demarne; Serre; Lacour; Gougat; Gagnol; Gautier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 11 - 20

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Citation Number: 2

Abstract

Abstract New indolyloxypropanolamines in which the substituent at the side chain nitrogen atom was the 2-(1H-indol-3yl)-1, 1-dimethylethyl group have been synthesized as putative anti-hypertensive agents. In vitro assays were used to measure their affinity for the β 1-, β 2, α 1-and α 2-adrenoceptors, where a marked tendency towards β 2-adrenoceptor selectivity was observed.