Mechanism of the irreversible deactivation of arachidonate 5-lipoxygenase by 5, 6-dehydroarachidonate

EJ Corey, PT Lansbury Jr, JR Cashman…

Index: Corey, E. J.; Cashman, John R.; Kantner, Steven S.; Wright, Stephen W. Journal of the American Chemical Society, 1984 , vol. 106, # 5 p. 1503 - 1504

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Citation Number: 23

Abstract

rates of aerobic deactivation of the 5-lipoxygenase from rat basophilic leukemic cells (RBL- 1) by 5, 6-dehydroarachidonate (1) and its 7R deuterio form 3 were determined at 22" C in the concentration range 60-140 rM 1 or 3 by the method used previously6,'* with the results indicated in Figure 1. A value for