α-Functionalized phosphonylphosphinates: Synthesis and evaluation as transcarbamoylase inhibitors

A Flohr, A Aemissegger, D Hilvert

Index: Flohr, Alexander; Aemissegger, Andreas; Hilvert, Donald Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2633 - 2640

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Citation Number: 18

Abstract

Diverse α-methyl-substituted phosphonylphosphinates (PCPCX) are accessible from a protected, pentafluorophenylsulfonated phosphonylphosphinate via nucleophilic displacement. The utility of this route is demonstrated with several nitrogen nucleophiles. The resulting amine and amino acid phosphonylphosphinate derivatives were evaluated as inhibitors of Streptococcus faecalis ornithine transcarbamoylase (OTC). Compared with ...