The Journal of organic chemistry

Nitroaldol reaction in aqueous media: An important improvement of the Henry reaction

R Ballini, G Bosica

Index: Ballini, Roberto; Bosica, Giovanna Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 425 - 427

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Citation Number: 159

Abstract

Carbon-carbon bond formation is the essence of organic synthesis; the Henry reaction, an aldol-type reaction, represents one of the classical CC bond-forming processes, and its variants have been used extensively in many important syntheses. 1-19 The classical nitroaldol reaction is performed, as routine procedure, in presence of a base (Scheme 1) in an organic solvent. Since basic reagents are also catalysts for the aldol condensation and ...