Synlett

Asymmetric intramolecular allylic amination: Straightforward approach to chiral C1-substituted tetrahydroisoquinolines

K Ito, S Akashi, B Saito, T Katsuki

Index: Ito, Katsuji; Akashi, Suemi; Saito, Bunnai; Katsuki, Tsutomu Synlett, 2003 , # 12 p. 1809 - 1812

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Citation Number: 5

Abstract

Abstract Newly introduced Pd-catalyzed asymmetric intramolecular allylic amination provides an easy access to pharmaceutically important 1-substituted tetrahydroisoquinolines. With this amination as the key step,(R)-carnegine was synthesized in an enantioselective manner.