3'-Amino-2', 3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities

…, GA Freeman, SR Shaver, LM Beacham III…

Index: Krenitsky; Freeman; Shaver; Beacham III; Hurlbert; Cohn; Elwell; Selway Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 891 - 895

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Citation Number: 56

Abstract

3'-Amino-2', 3'-dideoxyribonucleosides of thymine, uracil, and 5-iodouracil (l-3) were synthesized from the corresponding 2'-deoxyribonucleosides via the threo-3'-chloro and the erythro-3'-azido derivatives. Corresponding aminonucleosides of 5-bromouracil, 5- chlorouracil, and 5-fluorouracil (4-6) were synthesized enzymatically with 3'-amino-2', 3'- dideoxythymidine as the aminopentosyl donor and thymidine phosphorylase (EC 2.4. 2.4) ...