An expedient route to aromatic pyrrolo [2, 1-c][1, 4] benzodiazepines and a study of their reactivity

…, J Sopkova-de Oliveira Santos, S Fouchet-Jolivet…

Index: Fabis, Frederic; Sopkova-de Oliveira Santos, Jana; Fouchet-Jolivet, Sandrine; Rault, Sylvain Tetrahedron Letters, 2001 , vol. 42, # 31 p. 5183 - 5185

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Citation Number: 9

Abstract

2-Hydroxypyrrolo [2, 1-c][1, 4] benzodiazepines were aromatised in refluxing thionyl chloride into 11-chloropyrrolo [2, 1-c][1, 4] benzodiazepines in high yield. This aromatic system is doubly reactive towards nucleophiles leading to rearranged products such as iminobenzoxazines and quinazolines.

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