Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect

…, M Barbic, G Juergenliemk, J Heilmann

Index: Vogel, Susanne; Barbic, Matej; Juergenliemk, Guido; Heilmann, Joerg European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2206 - 2213

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Citation Number: 85

Abstract

Besides 2′, 4′-dihydroxy-4, 6′-dimethoxy-3′-prenylchalcone (1) and 4-acetoxy-2′, 4′-dihydroxy-6′-methoxy-3′-prenylchalkon (2), both phase II metabolites of xanthohumol in rats, also a principally new chalcone 3′-coumaroyl-2′, 4, 4′-trihydroxy-6′- methoxychalcone (3), structurally derived from helichrysetin (4) by introducing a second coumaroyl substructure at C-3′ was synthesized. Furthermore new chalcones were ...

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