The Journal of organic chemistry

Synthesis of 11-deoxy-13, 14-dihydro-8-azaprostaglandin E1

PA Zoretic, J Chiang

Index: Zoretic,P.A.; Chiang,J. Journal of Organic Chemistry, 1977 , vol. 42, p. 2103 - 2105

Full Text: HTML

Citation Number: 9

Abstract

(9). The synthetic approach to 9 involves the construction of a 5-substituted 2-pysrolidinone nucleus containing an intact Cs side chain as outlined below (Scheme I). Reaction of n- hexanoyl chloride (1) with ethylene4 in the presence of AlC13 in chloroform at OC yielded a