Organic letters

Novel 2-pyridone synthesis via nucleophilic addition of malonic esters to alkynyl imines

I Hachiya, K Ogura, M Shimizu

Index: Hachiya, Iwao; Ogura, Kana; Shimizu, Makoto Organic Letters, 2002 , vol. 4, # 16 p. 2755 - 2757

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Citation Number: 34

Abstract

Nucleophilic addition to imines is one of the most important carbon−carbon bond formation reactions for the synthesis of nitrogen-containing compounds. For example, Lewis acid catalyzed imino aldol reactions of silyl enol ethers with aldimines are a useful method for the preparation of β-amino esters, which are readily converted into β-lactams and amino acids. 1 α,β-Unsaturated aldimines are also employed as electrophiles in not only imino aldol reactions 2 but also ...