(S)-Naproxen® as a derivatizing agent to determine enantiomeric excess of cyanohydrins by HPLC

A Soli, IP Herminia, N Manjarrez, R Sa, A Gutie

Index: Solis, Aida; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Sanchez, Remedios; Gutierrez, Atilano Tetrahedron Letters, 1998 , vol. 39, # 48 p. 8759 - 8762

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Citation Number: 13

Abstract

An easy, inexpensive and accurate method to determine enantiomeric excess of cyanohydrins is described. The method consists in derivatization of cyanohydrins with (S)- naproxen® chloride and the products analyzed by HPLC. The results of enantiomeric excess so determined are similar to those obtained with [Eu (hfc) 3], as a chiral shift reagent, and analysis by1H-NMR of the cyanohydrins.