Advanced Synthesis & Catalysis

Practical Synthesis of Polysubstituted Imidazoles via Iodine??Catalyzed Aerobic Oxidative Cyclization of Aryl Ketones and Benzylamines

H Huang, X Ji, W Wu, H Jiang

Index: Huang, Huawen; Ji, Xiaochen; Wu, Wanqing; Jiang, Huanfeng Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 170 - 180

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Citation Number: 34

Abstract

Abstract A practical synthetic method for polysubstituted imidazoles via iodine-catalyzed aerobic oxidative cyclization of aryl ketones and benzylamines has been developed. It was found to tolerate a broad range of substrates to prepare polysubstituted imidazole derivatives in a one-pot manner, and thus importantly allowed product diversity for imidazole chemistry. Additionally, the resultant 1, 2, 4-trisubstituted imidazoles could be conveniently ...

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