Synthesis and antimicrobial activity of novel bis-azaphenothiazines

K Kushwaha, R Sakhuja, SC Jain

Index: Kushwaha, Khushbu; Sakhuja, Rajeev; Jain, Subhash C. Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4459 - 4467

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Citation Number: 4

Abstract

Abstract N-alkylation of azaphenothiazines using dibromoalkanes or dibromoalkenes did not result in the formation of bis-azaphenothiazines under known conditions such as refluxing, for more than 100 h, with NaNH 2/xylene or NaH/toluene. However, when the same reaction was tried with NaH/DMF at− 5° C to rt, it yielded the desired product in 68– 71% yield. These novel bis-azaphenothiazines containing a suitable alkyl or alkenyl ...