Design and characterization of flavoenzyme models in the course of chemical evolution of four-α-helix bundle polypeptides

K Tomizaki, Y Tsunekawa, H Akisada…

Index: Tomizaki, Kin-Ya; Tsunekawa, Yoshiro; Akisada, Hideo; Mihara, Hisakazu; Nishino, Norikazu Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 4 p. 813 - 822

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Citation Number: 14

Abstract

The chemical evolution of four-α-helix bundle polypeptides to a flavoenzyme model was attempted by designing single-chain 53-peptides, which comprise flavin derivatives at three different positions. A pair of flavin derivatives were also introduced opposite to each other on the separate α-helix segments in the hydrophobic core. The four-α-helix bundle structure and the flavin moieties around the hydrophobic core were characterized by circular ...